R and D Services

SRIS SYNTHESIS having strong experience in optimization of several molecules including micro (milligram scale) to macro (Kilogram scale) in the sector of Contract research wing which includes Spiro, aliphatic series, peptides, Heterocyclic core moieties, Assymetric synthesis, Nucleosides and Nicleotides, Organo metallics and library synthesis. In addition to them, we are experienced in development of various API’s and their key Starting materials and raw materials in a non-infringement routes to meet the requirements of Regulatory Market and synthesis of target based antiviral, antihypertensive and antimalarial and Oncology therapeutics including hybrid molecules in a cost effective well set manner.

SRIS SYNTHESIS is well experienced in performing the reactions under extreme inert atmosphere conditions and moisture sensitive reagents like lithium diisopropylamide (LDA), n-butyllithium (n-BuLi), diisobutylaluminium hydride (DIBAL), alkyl-magnesium-halide reactions (stereo-selective Grignard reactions), arylmagnesium- halides generation and reactions involving (synthesis of chemo-selective symmetrical and unsymmetrical bisphenols), aryl-zinc-halides generation and reactions involving (synthesis of chemo-selective unsymmetrical bisphenols), Allenyl-magnesiumhalide reactions (synthesis of 5-butynyl and 5-methyl isoxozoles), Pd/C, H2 reductions, Pd-BaSO4-H2 partial reductions, pyridenium-p-tolunesulfonate catalyzed protections, tert-Butyldimethylsilyl chloride(TBDMS) protections, Tetrabutylammoniumfluoride (TBAF) reagent deprotections, Lithiumaluminium hydride reductions (LAH), Pyrideniumchlorochromate (PCC) oxidations, Pb(OAc)4 oxidative 1,2-diolclevage reactions.